N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Base Information

Chemical Name:N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide
CAS No.:1256488-43-3
Molecular Formula:C₂₇H₂₈N₂O₇S
Molecular Weight:524.595
Hs Code.:

Synonyms:N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

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Technology Process of N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

There total 11 articles about N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1256488-99-9
C₂₈H₃₀N₂O₇S

: 1256488-43-3
N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Guidance literature:: C₂₈H₃₀N₂O₇S; With hydrogen bromide; In acetic acid; at 65 ℃;

With sodium hydrogencarbonate; In water; acetic acid;

Reference yield:

: 856898-35-6
methyl 2-bromo-5-[(methylsulfonyl)amino]benzoate

: 1256488-43-3
N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / N,N-dimethyl-formamide / Inert atmosphere

1.2: 6 h / 75 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -30 - 20 °C

3.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 70 °C

4.1: gold(III) chloride / trifluoroacetic acid / 0.75 h / 100 °C / Sealed tube; Microwave Irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

6.1: hydrogen bromide / acetic acid / 65 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen bromide; sodium carbonate; triethylamine; gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid;

Reference yield:

: 1206776-41-1
4-bromo-2-tert-butyl-6-iodophenol

: 1256488-43-3
N-{3-[3-tert-butyl-2-methoxy-5-(6-methoxy-2-oxo-1,2-dihydro-pyridin-3-yl)-phenyl]-1-oxo-1H-isochromen-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 20 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 70 °C

3: gold(III) chloride / trifluoroacetic acid / 0.75 h / 100 °C / Sealed tube; Microwave Irradiation

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; dichloromethane / 0.5 h / 100 °C / Sealed tube; Microwave Irradiation

5: hydrogen bromide / acetic acid / 65 °C

With copper(l) iodide; hydrogen bromide; sodium carbonate; potassium carbonate; triethylamine; gold(III) chloride; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; trifluoroacetic acid;