N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

Base Information

Chemical Name:N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide
CAS No.:1296210-19-9
Molecular Formula:C₃₃H₄₁N₅O₂
Molecular Weight:539.721
Hs Code.:

Synonyms:N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

Chemical Property:

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Technology Process of N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

There total 10 articles about N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₈H₅₁N₅O₄

: 1296210-19-9
N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 25 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.01.040

Reference yield:

: 2417-73-4
methyl 2-bromomethylbenzoate

: 1296210-19-9
N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h

2: sodium hydroxide / tetrahydrofuran; methanol; water / 0.75 h / 80 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 48 h / 25 °C

4: pyridine / 25 °C / Cooling with ice

5: N-ethyl-N,N-diisopropylamine / methanol / 25 °C

6: methanol; sodium tetrahydroborate / 3 h / 25 °C

7: piperidine / N,N-dimethyl-formamide / 3 h / 25 °C

With piperidine; pyridine; methanol; sodium tetrahydroborate; oxalyl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.040

Reference yield:

: 1296210-23-5
(9H-fluoren-9-yl)methyl (8-aminooctyl)carbamate

: 1296210-19-9
N-(4-amino-2-methylquinolin-6-yl)-2-[4-(8-aminooctylaminomethyl)phenoxymethyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / methanol / 25 °C

2: methanol; sodium tetrahydroborate / 3 h / 25 °C

3: piperidine / N,N-dimethyl-formamide / 3 h / 25 °C

With piperidine; methanol; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.01.040