benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

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Chemical Name:benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate
CAS No.:361337-17-9
Molecular Formula:C₄₁H₄₀FN₅O₅
Molecular Weight:701.798
Hs Code.:

Synonyms:benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

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Chemical Property of benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

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Technology Process of benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

There total 9 articles about benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 361340-51-4
methyl (2-fluoro-6-hydroxy-3-nitrophenyl)acetate

: 361337-17-9
benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / -10 - 20 °C

2: Pd(PPh₃)4; LiCl / dioxane / 85 °C

3: Fe; AcOH / 80 °C

4: NaHB(OAc)3 / CH₂Cl₂; tetrahydrofuran

5: NaOH / methanol / 65 °C

6: HOBt; NMM; polystyrene-bound carbodiimide / CH₂Cl₂; dimethylformamide

With 4-methyl-morpholine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; polystyrene-bound carbodiimide; sodium tris(acetoxy)borohydride; iron; benzotriazol-1-ol; acetic acid; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 2: Stille coupling;
DOI:10.1016/j.bmcl.2003.08.002

Reference yield:

: 361337-15-7
methyl [3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetate

: 361337-17-9
benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol / 65 °C

2: HOBt; NMM; polystyrene-bound carbodiimide / CH₂Cl₂; dimethylformamide

With 4-methyl-morpholine; sodium hydroxide; polystyrene-bound carbodiimide; benzotriazol-1-ol; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.08.002

Reference yield:

: 361337-10-2
methyl (4-amino-3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-1,1'-biphenyl-2-yl)acetate

: 361337-17-9
benzyl {4-[({[3'-{[(benzyloxy)carbonyl]amino}-3-fluoro-4-(isopropylamino)-1,1'-biphenyl-2-yl]acetyl}amino)methyl]phenyl}(imino)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: NaHB(OAc)3 / CH₂Cl₂; tetrahydrofuran

2: NaOH / methanol / 65 °C

3: HOBt; NMM; polystyrene-bound carbodiimide / CH₂Cl₂; dimethylformamide

With 4-methyl-morpholine; sodium hydroxide; polystyrene-bound carbodiimide; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.08.002