(E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

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Chemical Name:(E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide
CAS No.:1569644-81-0
Molecular Formula:C₂₆H₃₀FN₃O₂
Molecular Weight:435.542
Hs Code.:

Synonyms:(E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

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Chemical Property of (E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

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Technology Process of (E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

There total 6 articles about (E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.2%

: 2925-01-1
3-fluoro-N'-isopropylbenzohydrazide

: 1569647-02-4
(E)-3-(1-isopentyl-1H-indol-3-yl)acrylic acid

: 1569644-81-0
(E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1204-06-4,29953-71-7
trans-3-indole-acrylic acid

: 1569644-81-0
(E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 72 h / 60 °C

2: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 50 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1002/bkcs.10123

Reference yield:

: 19626-92-7
trans-3-(3-indolyl)acrylsaeuremethylester

: 1569644-81-0
(E)-3-fluoro-N'-(3-(1-isopentyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 50 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/bkcs.10123