2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

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Chemical Name:2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile
CAS No.:1360055-72-6
Molecular Formula:C₃₃H₃₃FN₈O₃
Molecular Weight:608.675
Hs Code.:

2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

Synonyms:2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

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Chemical Property of 2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

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Technology Process of 2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

There total 19 articles about 2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612853-60-7
2-(2-{3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-formylphenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

: 1360055-72-6
2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

Guidance literature:: With methanol; sodium tetrahydroborate; In dichloromethane; at 20 ℃; for 0.116667h; Cooling with ice;

Reference yield:

: 1360056-99-0
4-(5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-3-ylamino)-6-chloro-2-methylpyridazin-3(2H)-one

: 1360055-72-6
2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; potassium acetate; XPhos / 1,4-dioxane / 0.27 h / 100 °C / Inert atmosphere

2: tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water; butan-1-ol / 1 h / 110 °C / Inert atmosphere

3: sodium tetrahydroborate; methanol / dichloromethane / 0.12 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; potassium acetate; palladium diacetate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; tricyclohexylphosphine; In 1,4-dioxane; dichloromethane; water; butan-1-ol;

Reference yield:

: 1360056-26-3
2,4,6-trifluoro-N-(2-hydroxy-1,1-dimethyl-ethyl)benzamide

: 1360055-72-6
2-(2-{ 3-[5-(5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl]-2-hydroxymethyl-phenyl}-8-fluoro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / dichloromethane / 20 °C / Cooling with ice

2.1: tetrahydrofuran; diethyl ether / 8 h / 0 - 20 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran / 2 h / -20 - 15 °C / Inert atmosphere

4.1: acetonitrile / 63 °C

5.1: sodium hydroxide; water / methanol / 1 h / 80 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

6.2: 4 h

7.1: tetrahydrofuran / 3 h / 63 °C

8.1: potassium tert-butylate / tetrahydrofuran / 2.25 h / 55 - 62 °C

9.1: sodium hydrogencarbonate; copper(l) iodide / dimethyl sulfoxide / 3.5 h / 110 °C / Inert atmosphere

10.1: tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water; butan-1-ol / 1 h / 110 °C / Inert atmosphere

11.1: sodium tetrahydroborate; methanol / dichloromethane / 0.12 h / 20 °C / Cooling with ice

With methanol; sodium tetrahydroborate; copper(l) iodide; thionyl chloride; potassium tert-butylate; water; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; acetonitrile; butan-1-ol;