3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ⁶-sulphanyl)benzoic acid

Base Information

• Chemical Name: 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ⁶-sulphanyl)benzoic acid
• CAS No.: 1448316-43-5
• Molecular Formula: C₂₆H₂₀F₅N₅O₃S
• Molecular Weight: 577.535

Synonyms:3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ⁶-sulphanyl)benzoic acid

Chemical Property of 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ⁶-sulphanyl)benzoic acid

Chemical Property:

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Technology Process of 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ⁶-sulphanyl)benzoic acid

There total 8 articles about 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ⁶-sulphanyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N-{2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-formyl-5-(penta-fluoro-λ6-sulphanyl)benzamide (1448318-48-6) → 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ6-sulphanyl)benzoic acid (1448316-43-5)

Guidance literature:

With sodium chlorite; sodium dihydrogen phosphate monohydrate; In water; dimethyl sulfoxide; at 20 ℃; for 24h;

Reference yield:

nicotinoylacetonitrile (30510-18-0) → 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ6-sulphanyl)benzoic acid (1448316-43-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 4 h / Reflux

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

3.1: sulfuric acid / ethanol / 0.25 h / 130 °C / Microwave irradiation

4.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 2.5 h / Reflux

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

5.2: 1.5 h / 20 °C

6.1: sodium dihydrogen phosphate monohydrate; sodium chlorite / water; dimethyl sulfoxide / 24 h / 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; sulfuric acid; palladium 10% on activated carbon; ammonium formate; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine (222056-48-6) → 3-({2,4-dimethyl-5-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}carbamoyl)-5-(penta-fluoro-λ6-sulphanyl)benzoic acid (1448316-43-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

2.1: sulfuric acid / ethanol / 0.25 h / 130 °C / Microwave irradiation

3.1: palladium 10% on activated carbon; ammonium formate / ethanol; water / 2.5 h / Reflux

4.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

4.2: 1.5 h / 20 °C

5.1: sodium dihydrogen phosphate monohydrate; sodium chlorite / water; dimethyl sulfoxide / 24 h / 20 °C

With sodium chlorite; sodium dihydrogen phosphate monohydrate; sulfuric acid; palladium 10% on activated carbon; ammonium formate; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

nicotinoylacetonitrile

1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

1-(2,2-diethoxyethyl)-N-(2,4-dimethyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

1-(2,4-dimethyl-5-nitrophenyl)-6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazole

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