2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide

Base Information

• Chemical Name: 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide
• CAS No.: 1022964-12-0
• Molecular Formula: C₂₅H₂₇ClN₆O₂
• Molecular Weight: 478.981
• Mol file: 1022964-12-0.mol

Synonyms:2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide

Chemical Property of 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide

There total 7 articles about 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-7-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepin-2-one (53841-98-8) + 2-(2,5-dichloro-pyrimidin-4-ylamino)-N-propyl-benzamide (1022964-04-0) → 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide (1022964-12-0)

Guidance literature:

With camphor-10-sulfonic acid; In isopropyl alcohol; at 140 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

2-(propylcarbamoyl-phenyl)-carbamic acid tert-butyl ester (1022964-01-7) → 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide (1022964-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 90 °C

3: camphor-10-sulfonic acid / isopropyl alcohol / 0.33 h / 140 °C / Microwave irradiation

With camphor-10-sulfonic acid; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2010.11.045

Reference yield:

1-methyl-7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-2-one (1022954-12-6) → 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-propyl-benzamide (1022964-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10% palladium on activated carbon; hydrazine hydrate / ethanol / 60 °C

2: camphor-10-sulfonic acid / isopropyl alcohol / 0.33 h / 140 °C / Microwave irradiation

With 10% palladium on activated carbon; camphor-10-sulfonic acid; hydrazine hydrate; In ethanol; isopropyl alcohol;

DOI:10.1016/j.bmcl.2010.11.045

upstream raw materials:

2-(propylcarbamoyl-phenyl)-carbamic acid tert-butyl ester

1-methyl-7-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepin-2-one

2-(2,5-dichloro-pyrimidin-4-ylamino)-N-propyl-benzamide

1-methyl-7-nitro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-2-one