(R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

Base Information

Chemical Name:(R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol
CAS No.:497882-28-7
Molecular Formula:C₂₀H₃₀O₇S
Molecular Weight:414.52
Hs Code.:

Synonyms:(R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

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Chemical Property of (R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

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Technology Process of (R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

There total 4 articles about (R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 497882-27-6
Acetic acid (R)-1-((4R,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propyl ester

: 497882-28-7
(R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

Guidance literature:: With sodium carbonate; In methanol; water; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(02)00998-5

Reference yield:

: (E)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-5-(toluene-4-sulfonyl)-pent-1-en-3-one

: 497882-28-7
(R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: CeCl₃*7H₂O; NaBH₄ / methanol / 0.5 h

2.1: 0.65 g / pyridine; N,N-dimethylpyridin-4-amine / CH₂Cl₂ / 3 h / 20 °C

3.1: N-methylmorpholine N-oxide; OsO₄ / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 18 h / 20 °C

3.2: 65 percent / 4-methylbenzenesulfonic acid / acetone / 3 h / 20 °C / pH 5

4.1: 88 percent / sodium carbonate / methanol; H₂O / 24 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; osmium(VIII) oxide; cerium(III) chloride; sodium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(02)00998-5

Reference yield:

: 497882-25-4
(E)-(R)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-5-(toluene-4-sulfonyl)-pent-1-en-3-ol

: 497882-28-7
(R)-1-((4R,5R,4'R)-2,2,2',2'-Tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-3-(toluene-4-sulfonyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.65 g / pyridine; N,N-dimethylpyridin-4-amine / CH₂Cl₂ / 3 h / 20 °C

2.1: N-methylmorpholine N-oxide; OsO₄ / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 18 h / 20 °C

2.2: 65 percent / 4-methylbenzenesulfonic acid / acetone / 3 h / 20 °C / pH 5

3.1: 88 percent / sodium carbonate / methanol; H₂O / 24 h / 20 °C

With pyridine; dmap; osmium(VIII) oxide; sodium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(02)00998-5