trans-3-Methyl-5-phenyl-1-methylidenecyclohexane

Base Information

• Chemical Name: trans-3-Methyl-5-phenyl-1-methylidenecyclohexane
• CAS No.: 28467-40-5
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.269
• Mol file: 28467-40-5.mol

Synonyms:trans-3-Methyl-5-phenyl-1-methylidenecyclohexane

Chemical Property of trans-3-Methyl-5-phenyl-1-methylidenecyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-3-Methyl-5-phenyl-1-methylidenecyclohexane

There total 19 articles about trans-3-Methyl-5-phenyl-1-methylidenecyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-methylcyclohex-2-en-1-one (7214-50-8) + phenyllithium (591-51-5) → trans-3-Methyl-5-phenyl-1-methylidenecyclohexane (28467-40-5)

Guidance literature:

With copper(I) thiocyanate; In diethyl ether; at -78 ℃; for 1h; Mechanism; Product distribution; other reagents: CuI;

DOI:10.1021/jo00152a026

Reference yield:

5-methylcyclohex-2-en-1-one (7214-50-8) + phenylzinc chloride (28557-00-8) → cis-3-Methyl-5-phenyl-1-methylidenecyclohexane (28467-39-2,28467-40-5,60741-75-5) + trans-3-Methyl-5-phenyl-1-methylidenecyclohexane (28467-40-5)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at 0 ℃; for 0.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol300387f

Reference yield:

5-methylcyclohex-2-en-1-one (7214-50-8) + phenylzinc chloride (28557-00-8) → cis-3-Methyl-5-phenyl-1-methylidenecyclohexane (28467-39-2,28467-40-5,60741-75-5) + trans-3-Methyl-5-phenyl-1-methylidenecyclohexane (28467-40-5)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at 0 ℃; for 0.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol300387f

upstream raw materials:

5-methyl-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one

(E)-benzalacetone

4-Phenyl-6-phenylsulfanylmethyl-hept-6-en-2-one

4-Phenyl-6-phenylsulfanylmethyl-hept-6-en-2-ol