trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

Base Information

Chemical Name:trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate
CAS No.:1402008-44-9
Molecular Formula:C₁₈H₂₆N₅O₄*Li
Molecular Weight:383.377
Hs Code.:

Synonyms:trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

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Chemical Property of trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

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Technology Process of trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

There total 4 articles about trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402008-43-8
trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexanecarboxylic acid methyl ester

: 1402008-44-9
trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 50738-63-1
trans-4-aminomethyl-cyclohexanecarboxylic acid methyl ester

: 1402008-44-9
trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -78 °C

1.2: 16 h / 20 °C

2.1: H-CUBE apparatus (flow 1 mL, full H₂) with a Pd/C cartridge / methanol

2.2: 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 4 h

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1402008-42-7
trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-8-oxo-7,8-dihydro-purin-9 ylmethyl}-cyclohexanecarboxylic acid methyl ester

: 1402008-44-9
trans-4-{2-[(2-methoxy-ethyl)-methyl-amino]-7-methyl-8-oxo-7,8-dihydro-purin-9-ylmethyl}-cyclohexane lithium carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 4 h

2.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; caesium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;