BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Base Information

Chemical Name:BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide
CAS No.:136630-68-7
Molecular Formula:C₄₀H₆₂N₈O₇
Molecular Weight:766.982
Hs Code.:

Synonyms:BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Suppliers and Price of BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Technology Process of BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

There total 1 articles about BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 118700-84-8
(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

: 136735-33-6
H-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 136630-68-7
BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 136630-68-7
BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

: 136630-78-9
H-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 136630-68-7
BOC-Phe-β-Ala-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

: 136630-98-3
(2-{(S)-1-[2-((1S,2S)-3-{(1S,2S)-1-[(4-Amino-2-methyl-pyrimidin-5-ylmethyl)-carbamoyl]-2-methyl-butylcarbamoyl}-1-cyclohexylmethyl-2-hydroxy-propylcarbamoyl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-1,1-dimethyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4N aq. HCl / dioxane / 1 h / Ambient temperature

2: 64 percent / N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016