Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester
CAS No.:127230-21-1
Molecular Formula:C₂₈H₄₁NO₇S₂
Molecular Weight:567.768
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

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Chemical Property of Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

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Technology Process of Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

There total 5 articles about Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122226-01-1
3-<(tert-butyloxy)carbonyl>-4-(cyclohexylmethyl)-2,2-dimethyl-5-vinyloxazolidine

: 127230-21-1
Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: 61 percent / Zn / tetrahydrofuran / 1 h / 50 °C

3: H₂ / 10percent Pd/C / methanol / 3040 Torr

4: 1.) 4 M HCl, EtOH, 2.) a) LiAlH₄ / 1.) dioxane, 30 min, 2.) a) THF, 0 deg C, 30 min, b) CHCl₃, reflux, 16 h

With hydrogenchloride; lithium aluminium tetrahydride; ethanol; hydrogen; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00168a009

Reference yield:

: 104856-05-5,104856-06-6,114457-57-7,147373-31-7
(3RS,4S)-4-<(tert-butyloxy)carbonyl>-5-(cyclohexylmethyl)-3-hydroxy-1-pentene

: 127230-21-1
Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 1 h / Ambient temperature

3: 61 percent / Zn / tetrahydrofuran / 1 h / 50 °C

4: H₂ / 10percent Pd/C / methanol / 3040 Torr

5: 1.) 4 M HCl, EtOH, 2.) a) LiAlH₄ / 1.) dioxane, 30 min, 2.) a) THF, 0 deg C, 30 min, b) CHCl₃, reflux, 16 h

With hydrogenchloride; lithium aluminium tetrahydride; ethanol; hydrogen; pyridinium p-toluenesulfonate; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00168a009

Reference yield:

: 117997-58-7
tert-butyl (4S,5R)-4-(cyclohexylmethyl)-5-formyl-2,2-dimethyl-3-oxazolidinecarboxylate

: 127230-21-1
Toluene-4-sulfonic acid (2S,4S,5R,6S)-7-cyclohexyl-4,5-dihydroxy-2-methyl-6-(toluene-4-sulfonylamino)-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / Zn / tetrahydrofuran / 1 h / 50 °C

2: H₂ / 10percent Pd/C / methanol / 3040 Torr

3: 1.) 4 M HCl, EtOH, 2.) a) LiAlH₄ / 1.) dioxane, 30 min, 2.) a) THF, 0 deg C, 30 min, b) CHCl₃, reflux, 16 h

With hydrogenchloride; lithium aluminium tetrahydride; ethanol; hydrogen; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00168a009