(S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Base Information

Chemical Name:(S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate
CAS No.:129149-61-7
Molecular Formula:C₁₆H₂₄Cl₂NO₄P
Molecular Weight:396.251
Hs Code.:

Synonyms:(S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

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Chemical Property of (S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

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Technology Process of (S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

There total 5 articles about (S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63126-47-6
(2S)-2-(methoxymethyl)-1-pyrrolidine

: 129149-61-7
(S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / diisopropylethylamine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

2: 1.) n-BuLi / 1.) THF, 0 deg C, 2.) 0 deg C, 1 h

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja00175a030

Reference yield:

: 120-83-2,40477-79-0
2,4-dichlorophenol

: 129149-61-7
(S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 14.20 g / phosphoryl chloride, magnesium / 6 h / Heating

2: 7.53 g / magnesium / 5 h / Heating

3: 65 percent / diisopropylethylamine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

4: 1.) n-BuLi / 1.) THF, 0 deg C, 2.) 0 deg C, 1 h

With n-butyllithium; magnesium; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane;
DOI:10.1021/ja00175a030

Reference yield:

: 19430-75-2
2,4-dichlorophenylphosphorodichloridate

: 129149-61-7
(S)-butyl 2,4-dichlorophenyl 1-<(2S)-2-(methoxymethyl)pyrrolidinyl>phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 7.53 g / magnesium / 5 h / Heating

2: 65 percent / diisopropylethylamine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, overnight

3: 1.) n-BuLi / 1.) THF, 0 deg C, 2.) 0 deg C, 1 h

With n-butyllithium; magnesium; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ja00175a030