N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide

Base Information

• Chemical Name: N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide
• CAS No.: 1622093-55-3
• Molecular Formula: C₃₉H₃₈N₈O₃
• Molecular Weight: 666.783
• Mol file: 1622093-55-3.mol

Synonyms:N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide

Chemical Property of N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide

There total 5 articles about N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-(prop-2-yn-1-yloxy)phenyl)-1H-phenanthro[9,10-d]imidazole (1622093-52-0) + C15H22N6O2 (1622093-54-2) → N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide (1622093-55-3)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; In water; tert-butyl alcohol; at 140 ℃; for 5h;

DOI:10.1016/j.bbagen.2014.05.005

Reference yield:

3-chloro-N-(4-nitrophenyl)propanamide (19313-88-3) → N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide (1622093-55-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran; methanol / 16 h / 0 - 20 °C

2: palladium on activated charcoal / N,N-dimethyl-formamide / 4 h / 20 °C

3: hydrogenchloride; tert.-butylnitrite; sodium azide / water

4: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 5 h / 140 °C

With hydrogenchloride; sodium azide; tert.-butylnitrite; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bbagen.2014.05.005

Reference yield:

4-nitro-aniline (100-01-6,104810-17-5) → N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-3-(4-(2-hydroxyethyl)piperazin-1-yl)propanamide (1622093-55-3)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / tetrahydrofuran / 16 h / 0 - 50 °C

2: tetrahydrofuran; methanol / 16 h / 0 - 20 °C

3: palladium on activated charcoal / N,N-dimethyl-formamide / 4 h / 20 °C

4: hydrogenchloride; tert.-butylnitrite; sodium azide / water

5: sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 5 h / 140 °C

With hydrogenchloride; sodium azide; tert.-butylnitrite; copper(ll) sulfate pentahydrate; sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; palladium on activated charcoal; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.bbagen.2014.05.005

upstream raw materials:

4-nitro-aniline

3-chloro-N-(4-nitrophenyl)propanamide

C₁₅H₂₂N₄O₄

C₁₅H₂₄N₄O₂