(Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

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Chemical Name:(Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester
CAS No.:80523-27-9
Molecular Formula:C₂₃H₂₂ClN₃O₈S
Molecular Weight:535.962
Hs Code.:

Synonyms:(Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

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Chemical Property of (Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

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Technology Process of (Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

There total 3 articles about (Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80523-26-8
(R)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

: 80523-27-9
(Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

Guidance literature:: With ozone; Yield given. Multistep reaction; 1.) CH₂Cl₂, - 78 deg c;
DOI:10.1016/S0040-4039(01)81996-1

Reference yield:

: (R)-2-[(2R,3R)-2-Chloromethanesulfinyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

: 80523-27-9
(Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PBr₃

2: O₃ / 1.) CH₂Cl₂, - 78 deg c

With phosphorus tribromide; ozone;
DOI:10.1016/S0040-4039(01)81996-1

Reference yield:

: 61375-83-5
(R)-2-[(2R,3R)-2-Chlorosulfinyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester

: 80523-27-9
(Z)-2-[(2R,3R)-2-Chloromethylsulfanyl-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) HCl / 1.) - 20 deg C, CH₂Cl₂ 2.) - 20 deg C

2: PBr₃

3: O₃ / 1.) CH₂Cl₂, - 78 deg c

With hydrogenchloride; phosphorus tribromide; ozone;
DOI:10.1016/S0040-4039(01)81996-1