(R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

Base Information

Chemical Name:(R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone
CAS No.:851428-76-7
Molecular Formula:C₂₀H₂₄N₂O₄S
Molecular Weight:388.488
Hs Code.:

Synonyms:(R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

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Technology Process of (R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

There total 3 articles about (R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 851428-66-5
2-(N-allyl-N-carbethoxy-amino)-5-methyl-thiophene-3-carbaldehyde

: 321174-47-4
(R)-α-(hydroxymethyl)benzylhydroxylamine

: 851428-76-7
(R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

Guidance literature:: With magnesium sulfate; In diethyl ether; at 20 ℃; for 72h;
DOI:10.1016/j.tet.2005.01.121

Reference yield:

: 720686-86-2
2-(N-carbethoxy-amino)-5-methyl-thiophene

: 851428-76-7
(R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / NaH / tetrahydrofuran / 24 h / Heating

2: 62 percent / POCl₃ / CCl₄ / 24 h / Heating

3: 74 percent / MgSO₄ / diethyl ether / 72 h / 20 °C

With sodium hydride; magnesium sulfate; trichlorophosphate; In tetrahydrofuran; tetrachloromethane; diethyl ether; 2: Vilsmeier formylation;
DOI:10.1016/j.tet.2005.01.121

Reference yield:

: 851428-63-2
2-(N-allyl-N-carbethoxy-amino)-5-methyl-thiophene

: 851428-76-7
(R)-N-(α-hydroxymethylbenzyl)-C-[5-methyl-2-(N-carbethoxy-allylamino)-thien-3-yl]nitrone

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / POCl₃ / CCl₄ / 24 h / Heating

2: 74 percent / MgSO₄ / diethyl ether / 72 h / 20 °C

With magnesium sulfate; trichlorophosphate; In tetrachloromethane; diethyl ether; 1: Vilsmeier formylation;
DOI:10.1016/j.tet.2005.01.121