Chemical Property of Alpidem
Chemical Property:
- Appearance/Colour:white to off-white solid
- Melting Point:136-138 °C
- Refractive Index:1.606
- PKA:4.74±0.50(Predicted)
- PSA：37.61000
- Density:1.24 g/cm3
- LogP:5.49920
- Storage Temp.:Refrigerator
- Solubility.:DMSO: ≥10mg/mL
- XLogP3:4.8
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:7
- Exact Mass:403.1218178
- Heavy Atom Count:27
- Complexity:478
- Purity/Quality:
-
97% *data from raw suppliers
Alpidem *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCN(CCC)C(=O)CC1=C(N=C2N1C=C(C=C2)Cl)C3=CC=C(C=C3)Cl
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Description
Alpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is
claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the
omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior
to buspirone and similar to the benzodiazepines, but is significantly better tolerated
with lower abuse potential.
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Uses
A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic
