2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole
CAS No.:1398648-15-1
Molecular Formula:C₂₃H₁₆F₄N₂O₃S
Molecular Weight:476.451
Hs Code.:

Synonyms:2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

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Chemical Property of 2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

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Technology Process of 2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

There total 4 articles about 2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1391739-44-8
C₉H₈N₂O₃S

: 1398648-15-1
2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

Guidance literature:: With potassium hydroxide; In acetonitrile; at 85 ℃; for 3h;
DOI:10.1016/j.bmc.2012.05.055

Reference yield:

: 617-05-0
ethyl vanillate

: 1398648-15-1
2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 20 h / Reflux

2: potassium hydroxide / ethanol / 20 h / Reflux

3: potassium hydroxide / acetonitrile / 3 h / 85 °C

With hydrazine hydrate; potassium hydroxide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.05.055

Reference yield:

: 100377-63-7
4-hydroxy-3-methoxybenzoic hydrazide

: 1398648-15-1
2-(4-((2,6-difluorobenzyl)oxy)-3-methoxyphenyl)-5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 h / Reflux

2: potassium hydroxide / acetonitrile / 3 h / 85 °C

With potassium hydroxide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.05.055