4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine

Base Information

• Chemical Name: 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine
• CAS No.: 122252-89-5
• Molecular Formula: C₂₂H₂₁FN₂O₂
• Molecular Weight: 364.419

Synonyms:4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine

Chemical Property of 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine

Chemical Property:

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Technology Process of 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine

There total 6 articles about 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,4-dihydro-4-(4-fluorophenyl)-2-isopropyl-6-phenylpyrimidine-3-carboxylic acid ethyl ester (122930-46-5) → 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine (122252-89-5)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; at 50 ℃; for 3h;

DOI:10.1021/jm00163a010

Reference yield:

2-phenyl-4-(4-fluorophenyl)-4-carbethoxy-6-isopropyl-1,6-dihydropyrimidine → 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine (122252-89-5)

Guidance literature:

With bunazosin; In tetrahydrofuran;

Reference yield:

4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-1,2-dihydropyrimidine (147194-62-5) + 2,3-Dichloro-5,6-dicyanobenzoquinone (DDQ) → 4-(4-fluorophenyl)-6-(1-methylethyl)-2-phenyl-5-ethoxycarbonyl-pyrimidine (122252-89-5)

Guidance literature:

In hexane; ethyl acetate; toluene;

upstream raw materials:

1,4-dihydro-4-(4-fluorophenyl)-2-isopropyl-6-phenylpyrimidine-3-carboxylic acid ethyl ester

benzamidine monohydrochloride

4-fluorobenzaldehyde

ethyl 4-methyl-3-oxo-pentanoate

Downstream raw materials:

[2-phenyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-5-yl]-methanol

5-Bromomethyl-4-(4-fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidine

(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidin-5-yl]-vinyl}-tetrahydro-pyran-2-one

(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-6-isopropyl-2-phenyl-pyrimidin-5-yl]-vinyl}-tetrahydro-pyran-2-ol

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