3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

Base Information

Chemical Name:3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde
CAS No.:1229244-93-2
Molecular Formula:C₁₂H₁₃BrF₂O₂
Molecular Weight:307.135
Hs Code.:

Synonyms:3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

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Chemical Property of 3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

Chemical Property:

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Technology Process of 3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

There total 5 articles about 3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₅BrF₂O₂

: 1229244-93-2
3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

Guidance literature:: C₁₂H₁₅BrF₂O₂; With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.666667h;

With hydrogenchloride; water; In dichloromethane;

Reference yield:

: 1229245-00-4
methyl 3-bromo-5-[(1E)-3-methoxy-1-propen-1-yl]-4-methylbenzoate

: 1229244-93-2
3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / Crabtree's catalyst / dichloromethane / 20 °C

2: chloroform / 20 °C / Darkness

3: hydrogenchloride; water / diethyl ether

4: 2,2-difluoro-2-(fluorosulfonyl)acetic acid; sodium sulfate / acetonitrile / 16.17 h / 50 °C

5: diisobutylaluminium hydride / dichloromethane / 1.5 h / 20 °C

6: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.67 h / 20 °C

With hydrogenchloride; 2,2-difluoro-2-(fluorosulfonyl)acetic acid; water; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; sodium sulfate; Crabtree's catalyst; In diethyl ether; dichloromethane; chloroform; acetonitrile;

Reference yield:

: 74896-66-5
Methyl 3,5-Dibromo-4-methylbenzoate

: 1229244-93-2
3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / trans-dichlorobis(triphenylphosphine)palladium(II) / water; N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere of nitrogen

2: hydrogen / Crabtree's catalyst / dichloromethane / 20 °C

3: chloroform / 20 °C / Darkness

4: hydrogenchloride; water / diethyl ether

5: 2,2-difluoro-2-(fluorosulfonyl)acetic acid; sodium sulfate / acetonitrile / 16.17 h / 50 °C

6: diisobutylaluminium hydride / dichloromethane / 1.5 h / 20 °C

7: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.67 h / 20 °C

With hydrogenchloride; 2,2-difluoro-2-(fluorosulfonyl)acetic acid; water; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; sodium carbonate; Dess-Martin periodane; sodium sulfate; trans-dichlorobis(triphenylphosphine)palladium(II); Crabtree's catalyst; In diethyl ether; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; 1: Suzuki Coupling;