3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutanone

Base Information

• Chemical Name: 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutanone
• CAS No.: 2475-90-3
• Molecular Formula: C8H13 N O2
• Molecular Weight: 155.197
• Mol file: 2475-90-3.mol

Synonyms:1,3-Cyclobutanedione,2,2,4,4-tetramethyl-, monooxime (9CI); 1,3-Cyclobutanedione, tetramethyl-,oxime (7CI); NSC 147608

Chemical Property of 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutanone

Chemical Property:

• Vapor Pressure: 0.00831mmHg at 25°C
• Boiling Point: 247.3°Cat760mmHg
• Flash Point: 103.4°C
• Density: 1.11g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutanone

There total 5 articles about 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(2,2,4,4-tetramethyl-3-oxocyclobutylidene)-t-butylamine N-oxide (121080-27-1) → 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutan-1-one (2475-90-3)

Guidance literature:

at 150 ℃; for 1h;

DOI:10.1039/P29880002093

Reference yield: 67.4%

2,2,4,4-tetramethyl-1,3-cyclobutanedione (933-52-8) → 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutan-1-one (2475-90-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; water; for 2h; Reflux;

DOI:10.1021/jm201059s

Reference yield:

N-(2,2,4,4-tetramethyl-3-oxocyclobutylidene)-t-butylamine N-oxide (121080-27-1) → 3-(hydroxyimino)-2,2,4,4-tetramethylcyclobutan-1-one (2475-90-3) + isobutene (115-11-7,15220-85-6)

Guidance literature:

In 2,2,4-trimethylpentane; at 80 ℃; Rate constant;

DOI:10.1039/P29880002093

upstream raw materials:

N-(2,2,4,4-tetramethyl-3-oxocyclobutylidene)-t-butylamine N-oxide

3-tert-Butylimino-2,2,4,4-tetramethyl-cyclobutanone

2,2,4,4-tetramethyl-1,3-cyclobutanedione

Downstream raw materials:

3-amino-2,2,4,4-tetramethylcyclobutanol

(1r,3r)-3-amino-2,2,4,4-tetramethylcyclobutanol