(2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

Base Information

Chemical Name:(2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one
CAS No.:107691-86-1
Molecular Formula:C₂₄H₃₉NO₅Si
Molecular Weight:449.663
Hs Code.:

Synonyms:(2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

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Chemical Property of (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

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Technology Process of (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

There total 10 articles about (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82507-47-9
(S)-(-)-2,4-dimethylpent-4-en-1-ol

: 107691-86-1
(2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / SO₃, pyridine / dimethylsulfoxide; triethylamine / 3 h / 25 °C

2: 2.) H₂O₂ / 1.) -78 to 25 degC, 2h; 2.) MeOH, 1h, 0 degC

3: 85 percent / DMAP / CH₂Cl₂ / 15 h / Ambient temperature

4: 1.) C₆H₁₁BH₂, 2.) NaHCO₃, H₂O₂ / 1.) THF, 0 degC, 5h; 2.) RT, 12h

With pyridine; dmap; C₆H₁₁BH₂; sulfur trioxide; dihydrogen peroxide; sodium hydrogencarbonate; In dichloromethane; dimethyl sulfoxide; triethylamine;
DOI:10.1016/S0040-4039(00)84784-X

Reference yield:

: 82507-48-0
(S)-(+)-2,4-dimethylpent-4-enal

: 107691-86-1
(2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) H₂O₂ / 1.) -78 to 25 degC, 2h; 2.) MeOH, 1h, 0 degC

2: 85 percent / DMAP / CH₂Cl₂ / 15 h / Ambient temperature

3: 1.) C₆H₁₁BH₂, 2.) NaHCO₃, H₂O₂ / 1.) THF, 0 degC, 5h; 2.) RT, 12h

With dmap; C₆H₁₁BH₂; dihydrogen peroxide; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/S0040-4039(00)84784-X

Reference yield:

: 107691-84-9
(2'R,3'S,4R,4'S,5S)-(+)-3-(2'-ethyl-3'-hydroxy-4',6'-dimethyl-1'-oxohept-6'-enyl)-4-methyl-5-phenyloxazolidin-2-one

: 107691-86-1
(2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / DMAP / CH₂Cl₂ / 15 h / Ambient temperature

2: 1.) C₆H₁₁BH₂, 2.) NaHCO₃, H₂O₂ / 1.) THF, 0 degC, 5h; 2.) RT, 12h

With dmap; C₆H₁₁BH₂; dihydrogen peroxide; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/S0040-4039(00)84784-X