(2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

Base Information

Chemical Name:(2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)
CAS No.:1313744-67-0
Molecular Formula:C₄₁H₃₉N₅O₅
Molecular Weight:681.791
Hs Code.:

Synonyms:(2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

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Chemical Property of (2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

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Technology Process of (2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

There total 5 articles about (2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

: 118425-92-6
4,4'-(oxazole-2,5-diyl)dianiline

: 1313744-67-0
(2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm301796k

Reference yield:

: 54814-29-8
2,5-bis(4-nitrophenyl)oxazole

: 1313744-67-0
(2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 20% palladium hydroxide-activated charcoal / ethyl acetate; methanol / 6 h / 20 °C

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

With 20% palladium hydroxide-activated charcoal; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm301796k

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 118425-92-6
4,4'-(oxazole-2,5-diyl)dianiline

: 1313744-67-0
(2S,2'S)-N,N'-(4,4'-(oxazole-2,5-diyl)bis(4,1-phenylene))bis(1-(2-phenylacetyl)pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2012.11.086