C₂₁H₂₆O₂

Base Information

• Chemical Name: C₂₁H₂₆O₂
• CAS No.: 69474-09-5
• Molecular Formula: C₂₁H₂₆O₂
• Molecular Weight: 310.436
• Mol file: 69474-09-5.mol

Synonyms:C₂₁H₂₆O₂

Chemical Property of C₂₁H₂₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₆O₂

There total 3 articles about C₂₁H₂₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(+/-)-pentafluorophenyl 2-(4-isobutylphenyl)propionate (313520-42-2) + 1-Phenylethanol (98-85-1,13323-81-4) → C21H26O2 (69474-09-5)

Guidance literature:

1-Phenylethanol; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;

With zinc(II) chloride; In tetrahydrofuran;

(+/-)-pentafluorophenyl 2-(4-isobutylphenyl)propionate; In tetrahydrofuran; Further stages.;

DOI:10.1055/s-2008-1032068

Reference yield:

1-Phenylethanol (98-85-1,13323-81-4) + ibuprofen (15687-27-1,58560-75-1) → C21H26O2 (69474-09-5)

Guidance literature:

ibuprofen; With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.25h;

1-Phenylethanol; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jacs.9b02709

Reference yield:

1-Phenylethanol (98-85-1,13323-81-4) + 4-Nitrophenyl 2-(4-isobutylphenyl)propanoate (193149-67-6) → C21H26O2 (69474-09-5) + C21H26O2

Guidance literature:

With Candida antarctica lipase B (V₁₉₀C/A₂₈₁G/A₂₈₂V); In di-isopropyl ether; at 37 ℃; for 48h; Overall yield = 40 %; Overall yield = 279 mg; stereoselective reaction; Enzymatic reaction;

DOI:10.1021/jacs.9b02709

upstream raw materials:

(+/-)-pentafluorophenyl 2-(4-isobutylphenyl)propionate

1-Phenylethanol

ibuprofen

4-Nitrophenyl 2-(4-isobutylphenyl)propanoate