4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

Base Information

Chemical Name:4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide
CAS No.:299924-55-3
Molecular Formula:C₂₇H₃₀NOPS
Molecular Weight:447.581
Hs Code.:

Synonyms:4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

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Chemical Property of 4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

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Technology Process of 4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

There total 8 articles about 4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 299924-47-3
4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

: 299924-55-3
4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

Guidance literature:: With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol006323h

Reference yield:

: 299924-63-3
4,5-dimethyl-2-methoxycarbonyl-3,6-diphenyl-1-phospha-2,5-norbornadiene

: 299924-55-3
4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / S₈ / toluene / 12 h / 90 - 95 °C

2: LiI / pyridine / 20 h / 150 °C

3: 0.83 g / EDCl; HOBT / dimethylformamide / 0 - 20 °C

4: 92 percent / MsCl; Et₃N; DMAP / CH₂Cl₂ / 24 h / 20 °C

With sulfur; dmap; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium iodide; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Oxidation / 2: Hydrolysis / 3: Condensation / 4: Cyclization;
DOI:10.1021/ol006323h

Reference yield:

: 4,5-dimethyl-2-pethoxycarbonyl-3,6-diphenyl-1-phospha-2,5-norbornadiene

: 299924-55-3
4,5-dimethyl-3,6-diphenyl-2-(4-tert-butyloxazol-2-yl)-1-phospha-2,5-norbornadiene sulfide

Guidance literature:: Multi-step reaction with 4 steps

1: S₈ / toluene / 12 h / 90 - 95 °C

2: LiOH*H₂O / tetrahydrofuran; ethanol; H₂O / 15 h / 0 - 20 °C

3: 0.83 g / EDCl; HOBT / dimethylformamide / 0 - 20 °C

4: 92 percent / MsCl; Et₃N; DMAP / CH₂Cl₂ / 24 h / 20 °C

With sulfur; dmap; lithium hydroxide; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Oxidation / 2: Hydrolysis / 3: Condensation / 4: Cyclization;
DOI:10.1021/ol006323h