4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

Base Information

Chemical Name:4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one
CAS No.:173400-44-7
Molecular Formula:C₂₇H₃₅NO₆
Molecular Weight:469.578
Hs Code.:

Synonyms:4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

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Chemical Property of 4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

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Technology Process of 4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

There total 3 articles about 4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145589-03-3
(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one

: 172900-75-3
4-methoxy-3-(3-methoxypropoxy)benzaldehyde

: 173400-44-7
4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

: 172900-72-0
(4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: hydrogen; palladium / 70 °C / 9750.98 Torr / Inert atmosphere

With hydrogen; palladium; lithium diisopropyl amide; 1.1: |Knoevenagel Condensation / 1.2: |Knoevenagel Condensation;
DOI:10.1021/acs.oprd.5b00396

Reference yield:

: 145589-03-3
(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one

: 172900-73-1
4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene

: 173400-44-7
4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

Guidance literature:: (R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 1.25h;

4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene; In tetrahydrofuran; at -70 - 4 ℃; for 20h;

Reference yield:

: C₂₇H₃₃NO₆

: 173400-44-7
4(R)-benzyl-3-{2(S)-isopropyl-3-[4-methoxy-3-(3-methoxypropyloxy)-phenyl]-propionyl}-oxazolidin-2-one

: 172900-72-0
(4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one

Guidance literature:: With hydrogen; palladium; at 70 ℃; under 9750.98 Torr; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.oprd.5b00396