6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

Base Information

Chemical Name:6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester
CAS No.:197891-71-7
Molecular Formula:C₂₃H₂₂N₂O₆
Molecular Weight:422.437
Hs Code.:

Synonyms:6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

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Chemical Property of 6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

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Technology Process of 6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

There total 8 articles about 6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 197891-70-6
6-(Benzyloxycarbonyl-tert-butoxycarbonyl-amino)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

: 197891-71-7
6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; Ambient temperature;
DOI:10.1021/jm981026s

Reference yield:

: 136918-14-4,85-41-6
phthalimide

: 197891-71-7
6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / diethyl azodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

2: 98 percent / CF₃CO₂H / CH₂Cl₂ / Ambient temperature

With triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm981026s

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 197891-71-7
6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1 M Na₂CO₃ / CH₂Cl₂ / Ambient temperature

2: Et₃N, DMAP / acetonitrile / Ambient temperature

3: TsOH*pyridine, water / acetone / 45 °C

4: 70 percent / piperidine / acetonitrile / Ambient temperature

5: 85 percent / diethyl azodicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

6: 98 percent / CF₃CO₂H / CH₂Cl₂ / Ambient temperature

With piperidine; dmap; water; pyridinium p-toluenesulfonate; sodium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm981026s