3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

Base Information

Chemical Name:3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt
CAS No.:1345982-98-0
Molecular Formula:C₂₆H₃₆N₂O₇S₂*H₃N
Molecular Weight:569.744
Hs Code.:

3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

Synonyms:3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

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Chemical Property of 3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

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Technology Process of 3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

There total 7 articles about 3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1345984-10-2
N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-3-chloropropanamide

: 1345982-98-0
3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

Guidance literature:: N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-3-chloropropanamide; With sodium sulfite; In ethanol; water; at 60 ℃;

With acetic acid; In ethanol; water; at 20 ℃;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 1345983-52-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine

: 1345982-98-0
3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 4 h / 20 °C / Cooling with ice

2.1: sodium sulfite / ethanol; water / 60 °C

2.2: 20 °C

With pyridine; sodium sulfite; In ethanol; dichloromethane; water;

Reference yield:

: 1345983-39-2
(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl trifluoromethanesulfonate

: 1345982-98-0
3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-amino)-3-oxo-1-propanesulfonic acid ammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 2068.65 Torr

3: pyridine / dichloromethane / 4 h / 25 °C

4: water; sodium sulfite / ethanol / 60 °C

With pyridine; hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; sodium sulfite; zinc; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400459m