methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

Base Information

Chemical Name:methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate
CAS No.:1544662-80-7
Molecular Formula:C₃₀H₃₅F₆NO₃
Molecular Weight:571.603
Hs Code.:

Synonyms:methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

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Chemical Property of methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

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Technology Process of methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

There total 7 articles about methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75091-92-8,75091-93-9,30129-18-1
4-(trifluoromethyl)cyclohexan-1-ol

: 1544662-80-7
methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

3.1: ISCO column chromatography / Resolution of racemate

4.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

5.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride / ethanol / 5 h / 20 °C

6.2: 8 h / 20 °C / 3675.37 Torr

7.1: titanium(IV) isopropylate; sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

With titanium(IV) isopropylate; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; hydroxylamine hydrochloride; zirconium(IV) chloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1266120-65-3
4-(trifluoromethyl)cyclohexyl methanesulfonate

: 1544662-80-7
methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: ISCO column chromatography / Resolution of racemate

3.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride / ethanol / 5 h / 20 °C

5.2: 8 h / 20 °C / 3675.37 Torr

6.1: titanium(IV) isopropylate; sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

With titanium(IV) isopropylate; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; hydroxylamine hydrochloride; zirconium(IV) chloride; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1309977-21-6
6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthaldehyde

: 1544662-80-7
methyl 3-(((5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)methyl)amino)spiro[3.5]nonane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide; zirconium(IV) chloride / dichloromethane / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; copper(l) iodide / N,N-dimethyl-formamide / 5 h / 85 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride / ethanol / 5 h / 20 °C

3.2: 8 h / 20 °C / 3675.37 Torr

4.1: titanium(IV) isopropylate; sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 0.33 h / 100 °C / Microwave irradiation

With titanium(IV) isopropylate; N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; copper(l) iodide; hydroxylamine hydrochloride; zirconium(IV) chloride; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;