(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

Base Information

Chemical Name:(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate
CAS No.:1315334-33-8
Molecular Formula:C₄₈H₆₀N₄O₇S₃Si
Molecular Weight:929.311
Hs Code.:

(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

Synonyms:(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

There total 9 articles about (S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033814-13-9
(R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid

: C₃₄H₄₃NO₄SSi

: 1315334-33-8
(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: (R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxylic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

C₃₄H₄₃NO₄SSi; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2011.02.024

Reference yield:

: 297165-32-3
methyl 2-(tert-butoxycarbonylaminomethyl)thiazole-4-carboxylate

: 1315334-33-8
(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 0 - 20 °C

1.2: pH 1 - 2

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dichloromethane / 0.17 h

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 °C

4.1: sodium hydrogencarbonate / methanol / 2 h / 70 °C / pH 6 / aq. phosphate buffer

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

5.2: 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.02.024

Reference yield:

: 1043577-31-6
(S,E)-2-(trimethylsilyl)ethyl 3-(((S)-2-amino-3-methylbutanoyl)oxy)-7-(tritylthio)hept-4-enoate

: 1315334-33-8
(S,E)-2-(trimethylsilyl)ethyl 3-(3-((R)-2-(2-((tert-butoxycarbonylamino)methyl)thiazol-4-yl)-4-methyl-4,5-dihydrothiazole-4-carboxamido)propanoyloxy)-7-(tritylthio)hept-4-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2.1: diethylamine / 2 h

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C

3.2: 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2011.02.024