(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

Base Information

Chemical Name:(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde
CAS No.:1373497-79-0
Molecular Formula:C₁₅H₁₂O₃S
Molecular Weight:272.324
Hs Code.:

Synonyms:(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

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Technology Process of (E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

There total 2 articles about (E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 88-15-3,97511-16-5
2-Acetylthiophene

: 3328-73-2
4-hydroxy-5-methylisophthalaldehyde

: 1373497-79-0
(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

Guidance literature:: With boron trifluoride diethyl etherate; In 1,4-dioxane; at 20 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1248/cpb.c15-00939

Reference yield:

: 95-48-7,77504-84-8
ortho-cresol

: 1373497-79-0
(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 3 h / 120 °C

1.2: 2 h / 90 - 100 °C

2.1: hydrogenchloride / 1,4-dioxane; water / 80 - 90 °C

With hydrogenchloride; trifluoroacetic acid; In 1,4-dioxane; water; 1.1: Duff reaction;
DOI:10.1016/j.bmc.2012.03.011

Reference yield: 92.0%

: 1373497-79-0
(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 1373497-75-6
(E)-3-(3,4-dimethoxyphenyl)-8-methyl-6-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)-2H-chromen-2-one

Guidance literature:: 3,4,5-trimethoxyphenyl acetic acid; With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(E)-2-hydroxy-3-methyl-5-(3-oxo-3-(thiophen-2-yl)prop-1-enyl)benzaldehyde; In N,N-dimethyl-formamide; at 110 ℃; for 1.5h;
DOI:10.1055/s-0031-1290344