3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid

Base Information

• Chemical Name: 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid
• CAS No.: 1423134-88-6
• Molecular Formula: C₃₅H₄₇FN₄O₇
• Molecular Weight: 654.779
• Mol file: 1423134-88-6.mol

Synonyms:3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid

Chemical Property of 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid

There total 7 articles about 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-{3-[(3R)-3-{[1-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate (1423134-87-5) → 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid (1423134-88-6)

Guidance literature:

With barium hydroxide octahydrate; In methanol; at 20 ℃; for 20h;

Reference yield:

tert-butyl 4-{3-[(3R)-3-({1-[5-(3-hydroxyphenyl)pyridin-3-yl]-3-methoxy-3-oxopropyl} carbamoyl)piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate (1423134-86-4) → 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid (1423134-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / tetrahydrofuran / 354 h / 20 °C

2: barium hydroxide octahydrate / methanol / 20 h / 20 °C

With barium hydroxide octahydrate; caesium carbonate; In tetrahydrofuran; methanol;

Reference yield:

tert-butyl 4-{3-[(3R)-3-{[1-(5-bromopyridin-3-yl)-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate (1423134-92-2) → 3-({[(3R)-1-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propan oyl}piperidin-3-yl]carbonyl}amino)-3-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}propanoic acid (1423134-88-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / water; toluene; ethanol / 26 h / 100 °C

2: caesium carbonate / tetrahydrofuran / 354 h / 20 °C

3: barium hydroxide octahydrate / methanol / 20 h / 20 °C

With potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; barium hydroxide octahydrate; caesium carbonate; In tetrahydrofuran; methanol; ethanol; water; toluene; 1: |Suzuki Coupling;

upstream raw materials:

tert-butyl 4-{3-[(3R)-3-({1-[5-(3-hydroxyphenyl)pyridin-3-yl]-3-methoxy-3-oxopropyl} carbamoyl)piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

tert-butyl 4-{3-[(3R)-3-{[1-(5-bromopyridin-3-yl)-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

3-hydroxyphenylboronic acid

tert-butyl 4-{3-[(3R)-3-{[1-{5-[3-(2-fluoroethoxy)phenyl]pyridin-3-yl}-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate