Carmoxirole

Base Information

Chemical Name:Carmoxirole
CAS No.:98323-83-2
Molecular Formula:C24H26N2O2
Molecular Weight:374.483
Hs Code.:2933990090
UNII:MRP4P457ZA
DSSTox Substance ID:DTXSID0043892
Nikkaji Number:J398.459A
Wikidata:Q27133117
NCI Thesaurus Code:C81077
Metabolomics Workbench ID:63229
ChEMBL ID:CHEMBL70159
Mol file:98323-83-2.mol

Synonyms:carmoxirole;EMD 45609;EMD-45609

Suppliers and Price of Carmoxirole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Carmoxirole hydrochloride
10mg
$ 418.00

American Custom Chemicals Corporation
CARMOXIROLE HYDROCHLORIDE 95.00%
50MG
$ 1170.31

American Custom Chemicals Corporation
CARMOXIROLE HYDROCHLORIDE 95.00%
10MG
$ 697.34

Total 4 raw suppliers

Chemical Property of Carmoxirole

Chemical Property:

Vapor Pressure:2.63E-16mmHg at 25°C
Melting Point:284-285°
Boiling Point:621.5°C at 760 mmHg
Flash Point:329.7°C
PSA：56.33000
Density:1.21g/cm³
LogP:4.91600
Storage Temp.:Desiccate at +4°C
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:374.199428076
Heavy Atom Count:28
Complexity:555

Purity/Quality:

97% ^*data from raw suppliers

Carmoxirole hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC=C1C2=CC=CC=C2)CCCCC3=CNC4=C3C=C(C=C4)C(=O)O
Uses Carmoxirole is a selective, peripherally acting D2-like agonist.

Technology Process of Carmoxirole

There total 11 articles about Carmoxirole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 98323-99-0
Methyl-3-<4-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl>-5-indolcarboxylat

: 98323-83-2
3-<4-(1,2,3,6-Tetrahydro-4-phenyl-1-pyridyl)butyl>-5-indolcarbonsaeure

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; for 0.5h; Heating;

Reference yield: 91.0%

: 714950-75-1
3-[4-oxo-4-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-1H-indole-5-carboxylic acid

: 98323-83-2
3-<4-(1,2,3,6-Tetrahydro-4-phenyl-1-pyridyl)butyl>-5-indolcarbonsaeure

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2004.01.110

Reference yield:

: 3113-71-1
3-methyl-4-nitrobenzoic acid

: 98323-83-2
3-<4-(1,2,3,6-Tetrahydro-4-phenyl-1-pyridyl)butyl>-5-indolcarbonsaeure

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / pyrrolidine / dimethylformamide / 4 h / Heating

2: 75 percent / H₂ / 5percent Pd/C / toluene / 6 h

3: 1.) AlCl₃ / 1.) CH₂Cl₂, room temperature, 1 h, 2.) 3 h

4: 68 percent / NaBH₄, BF₃*OEt₂ / tetrahydrofuran / 0.5 h

5: 66 percent / NEt₃ / 3 h / Heating

6: 97 percent / 1N NaOH / dioxane; H₂O / 0.5 h / Heating

With pyrrolidine; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; boron trifluoride diethyl etherate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;