N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

Base Information

Chemical Name:N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide
CAS No.:1295645-14-5
Molecular Formula:C₃₃H₅₀N₂O₅
Molecular Weight:554.77
Hs Code.:

Synonyms:N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

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Chemical Property of N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

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Technology Process of N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

There total 11 articles about N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035229-44-7
(2,2-dimethoxyethyl)-((R)-1-methylpentyl)amine

: 1295644-40-4
3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

: 1295645-14-5
N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

Guidance literature:: 3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

(2,2-dimethoxyethyl)-((R)-1-methylpentyl)amine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 1295645-14-5
N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: trifluorormethanesulfonic acid / nitrobenzene / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

4.2: Cooling

5.1: N-benzyl-trimethylammonium hydroxide / toluene; methanol

5.2: 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

7.1: water / 1,2-dichloro-ethane / 0.17 h

7.2: 16 h

8.1: hydrogen / palladium on carbon / ethanol / 16 h / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h

9.2: 18 h / 20 °C

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; water; hydrogen; N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium on carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; nitrobenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1295645-14-5
N-(2,2-dimethoxyethyl)-3-{2-[4-hydroxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}-N-((R)-1-methylpentyl)propionamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: trifluorormethanesulfonic acid / nitrobenzene / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

4.2: Cooling

5.1: N-benzyl-trimethylammonium hydroxide / toluene; methanol

5.2: 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

7.1: water / 1,2-dichloro-ethane / 0.17 h

7.2: 16 h

8.1: hydrogen / palladium on carbon / ethanol / 16 h / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h

9.2: 18 h / 20 °C

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; water; hydrogen; N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium on carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; nitrobenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;