N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

Base Information

Chemical Name:N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide
CAS No.:1467739-05-4
Molecular Formula:C₁₇H₁₅ClN₆O₂
Molecular Weight:370.798
Hs Code.:

Synonyms:N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

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Chemical Property of N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

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Technology Process of N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

There total 3 articles about N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1467739-26-9
2-amino-6-(5-amino-2-methylphenylamino)pyrimidin-4(3H)-one

: 88912-27-0
3-chloro-isonicotinic acid

: 1467739-05-4
N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 90 ℃; for 12h; Inert atmosphere;
DOI:10.5012/bkcs.2013.34.8.2311

Reference yield:

: 99-55-8
2-methyl-5-nitroaniline

: 1467739-05-4
N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 3 h / 170 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 90 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2013.34.8.2311

Reference yield:

: 1467739-25-8
2-amino-6-(2-methyl-5-nitrophenylamino)pyrimidin-4(3H)-one

: 1467739-05-4
N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-3-chloroisonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 2 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 90 °C / Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2013.34.8.2311