3-(4'-fluorophenyl)isochromane

Base Information

• Chemical Name: 3-(4'-fluorophenyl)isochromane
• CAS No.: 214550-37-5
• Molecular Formula: C₁₅H₁₃FO
• Molecular Weight: 228.266
• Mol file: 214550-37-5.mol

Synonyms:3-(4'-fluorophenyl)isochromane

Chemical Property of 3-(4'-fluorophenyl)isochromane

Chemical Property:

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Technology Process of 3-(4'-fluorophenyl)isochromane

There total 1 articles about 3-(4'-fluorophenyl)isochromane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(4-Fluoro-phenyl)-2-(2-hydroxymethyl-phenyl)-ethanol → 3-(4'-fluorophenyl)isochromane (214550-37-5)

Guidance literature:

With silica-immobilized p-TsOH; In chloroform; for 1.5h; Heating;

DOI:10.1016/S0040-4039(98)01417-8

Reference yield: 58.0%

3-(4'-fluorophenyl)isochromane (214550-37-5) → 2-[2-oxo-2-(4'-fluorophenyl)ethyl]benzoic acid (54955-29-2) + 3,4-dihydro-3-(4'-fluorophenyl)isocoumarine

Guidance literature:

With 3,3-dimethyldioxirane; In acetone; at 20 ℃; for 8h;

DOI:10.1016/S0040-4020(99)00917-5

Reference yield:

3-(4'-fluorophenyl)isochromane (214550-37-5) → 3,4-dihydro-3-(4'-fluorophenyl)-H-2-benzopyran-1-ol + 3,4-dihydro-3-(4'-fluorophenyl)isocoumarine

Guidance literature:

With 3,3-dimethyldioxirane; In acetone; at 20 ℃; for 12h; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(99)00917-5

Downstream raw materials:

2-[2-oxo-2-(4'-fluorophenyl)ethyl]benzoic acid

3-(4-fluorophenyl)-1H-2-benzopyran-1-one