1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

Base Information

Chemical Name:1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate
CAS No.:1570178-35-6
Molecular Formula:C₂₆H₃₂N₂O₆S
Molecular Weight:500.616
Hs Code.:

Synonyms:1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

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Chemical Property of 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

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Technology Process of 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

There total 3 articles about 1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 387350-92-7
5-(methylsulfonyl)-2,3-dihydro-1H-indole

: 32315-10-9
bis(trichloromethyl) carbonate

: 1242429-10-2
benzyl 4-(2-hydroxypropyl)piperidine-1-carboxylate

: 1570178-35-6
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

Guidance literature:: bis(trichloromethyl) carbonate; benzyl 4-(2-hydroxypropyl)piperidine-1-carboxylate; With pyridine; In diethyl ether; at -40 - 0 ℃; Inert atmosphere;

5-(methylsulfonyl)-2,3-dihydro-1H-indole; With triethylamine; In tetrahydrofuran; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.01.028

Reference yield:

: 130312-10-6
benzyl 4-(2-oxoethyl)piperidine-1-carboxylate

: 1570178-35-6
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / 0 °C

2.1: pyridine / diethyl ether / -40 - 0 °C / Inert atmosphere

2.2: 19 h / 20 °C / Inert atmosphere

With pyridine; In tetrahydrofuran; diethyl ether;
DOI:10.1016/j.bmc.2014.01.028

Reference yield:

: 115909-91-6
1-(Benzyloxycarbonyl)-4-(2-hydroxyethyl)piperidine

: 1570178-35-6
1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}propan-2-yl 5-(methylsulfonyl)-2,3-dihydro-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 3 h / 20 °C

2.1: tetrahydrofuran / 4 h / 0 °C

3.1: pyridine / diethyl ether / -40 - 0 °C / Inert atmosphere

3.2: 19 h / 20 °C / Inert atmosphere

With pyridine; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2014.01.028