N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

Base Information

Chemical Name:N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide
CAS No.:367249-64-7
Molecular Formula:C₂₄H₂₀Cl₂N₂O₄
Molecular Weight:471.34
Hs Code.:

Synonyms:N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

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Technology Process of N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

There total 4 articles about N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 263387-98-0
N-[2-(S)-(3,4-dichlorophenyl)-4-hydroxybutyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

: 367249-64-7
N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

Guidance literature:: With dipyridinium dichromate; In N,N-dimethyl-formamide; for 4h;
DOI:10.1021/jm030197g

Reference yield:

: 160707-17-5
(S)-N-[2-(3,4-dichlorophenyl)-4-hydroxybutyl]-N-methylamine

: 367249-64-7
N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / aq. NaHCO₃ / CH₂Cl₂ / 20 °C

2: 84 percent / pyridinium dichromate / dimethylformamide / 4 h

With dipyridinium dichromate; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030197g

Reference yield:

: 263387-97-9
3-cyano-2-methoxy-1-naphthoic acid

: 367249-64-7
N-[2-(S)-(3,4-dichlorophenyl)-3-carboxypropyl]-N-methyl-3-cyano-2-methoxy-1-naphthamide

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2; DMF / CH₂Cl₂ / 3 h

2: 92 percent / aq. NaHCO₃ / CH₂Cl₂ / 20 °C

3: 84 percent / pyridinium dichromate / dimethylformamide / 4 h

With dipyridinium dichromate; oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030197g