1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

Base Information

Chemical Name:1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone
CAS No.:796969-06-7
Molecular Formula:C₁₉H₂₁N₅O₂
Molecular Weight:351.408
Hs Code.:

Synonyms:1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

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Chemical Property of 1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

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Technology Process of 1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

There total 9 articles about 1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935661-05-5
C₁₃H₁₅IN₄O₂

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 796969-06-7
1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 85 ℃; for 16h;
DOI:10.1021/jm061280h

Reference yield:

: 796968-53-1
2-fluoro-6-iodo-3-methoxybenzonitrile

: 796969-06-7
1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / BBr₃ / CH₂Cl₂ / 18 h / 20 °C

2: PPh₃ on resin; diethyl azodicarboxylate / tetrahydrofuran / 0 °C

3: hydrazine monohydrate / butan-1-ol / 5 h / 110 °C

4: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 16 h / 85 °C

With boron tribromide; sodium carbonate; hydrazine hydrate; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; butan-1-ol; 4: Suzuki coupling;
DOI:10.1021/jm061280h

Reference yield:

: 796968-52-0
2-fluoro-3-hydroxy-6-iodobenzonitrile

: 796969-06-7
1-(2-{[3-amino-4-(4-aminophenyl)-1H-indazol-7-yl]oxy}ethyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: PPh₃ on resin; diethyl azodicarboxylate / tetrahydrofuran / 0 °C

2: hydrazine monohydrate / butan-1-ol / 5 h / 110 °C

3: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 16 h / 85 °C

With sodium carbonate; hydrazine hydrate; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; butan-1-ol; 3: Suzuki coupling;
DOI:10.1021/jm061280h