1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Base Information

Chemical Name:1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA
CAS No.:1307809-74-0
Molecular Formula:C₂HF₃O₂*C₂₆H₂₅F₃N₂O₄
Molecular Weight:600.515
Hs Code.:

Synonyms:1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

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Chemical Property of 1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

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Technology Process of 1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

There total 9 articles about 1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1307809-73-9
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 1307809-74-0
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Guidance literature:: In methanol; water; acetonitrile;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307809-74-0
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.43 h / 0 °C

4.2: 0.18 h / 0 °C

4.3: 0.42 h / 20 - 110 °C

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 14 h / 20 °C

5.2: 0.5 h / 20 °C

6.1: methanol / acetic acid / 1,2-dichloro-ethane / 1.25 h / 20 - 80 °C

6.2: 0.5 h / 20 °C

7.1: acetonitrile; water; methanol

With pyridine; methanol; osmium(VIII) oxide; hydroxylamine hydrochloride; sodium acetate; 4-methylmorpholine N-oxide; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307809-74-0
1-((3-(4-isopropoxy-2-(trifluoromethyl)phenyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid TFA

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.43 h / 0 °C

3.2: 0.18 h / 0 °C

3.3: 0.42 h / 20 - 110 °C

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 14 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: methanol / acetic acid / 1,2-dichloro-ethane / 1.25 h / 20 - 80 °C

5.2: 0.5 h / 20 °C

6.1: acetonitrile; water; methanol

With methanol; osmium(VIII) oxide; hydroxylamine hydrochloride; sodium acetate; 4-methylmorpholine N-oxide; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; acetonitrile;