(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

Base Information

Chemical Name:(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine
CAS No.:1207729-75-6
Molecular Formula:C₁₅H₂₃NO₂S
Molecular Weight:281.419
Hs Code.:

Synonyms:(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

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Technology Process of (R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

There total 4 articles about (R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1227798-56-2
C₁₅H₂₄ClNO₂S

: 1207729-75-6
(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; water; for 24h; Reflux;
DOI:10.1039/b925209f

Reference yield:

: C₁₅H₂₄ClNO₂S

: 1207729-75-6
(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

Guidance literature:: With potassium tert-butylate; In isopropyl alcohol; at 50 ℃; for 1h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo4014386

Reference yield:

: 1227798-52-8
C₁₅H₂₂ClNO₂S

: 1207729-75-6
(R)-1-((R)-2-methyl-propane-2-sulfinyl)-2-(4-methoxyphenyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; potassium tert-butylate / 2 h / 50 °C / Molecular sieve; Inert atmosphere

2: potassium tert-butylate / isopropyl alcohol / 1 h / 50 °C / Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; In isopropyl alcohol;
DOI:10.1021/jo4014386