(S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

Base Information

Chemical Name:(S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester
CAS No.:132895-23-9
Molecular Formula:C₂₄H₃₂O₅Si
Molecular Weight:428.601
Hs Code.:

Synonyms:(S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

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Chemical Property of (S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

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Technology Process of (S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

There total 6 articles about (S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (S)-6-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-5-triethylsilanyloxy-hexanoic acid ethyl ester

: 132895-23-9
(S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

Guidance literature:: With acetic acid; In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.38.2890

Reference yield:

: 124655-05-6
(S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate

: 132895-23-9
(S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dimethylformamide / 0 °C

2: 93 percent / DIBAH / diethyl ether / -78 °C

3: 92 percent / LDA / tetrahydrofuran / -78 °C

4: 81 percent / PDC, MS-4A / CH₂Cl₂ / Ambient temperature

5: 96 percent / aq. AcOH / tetrahydrofuran / Ambient temperature

With dipyridinium dichromate; diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2890

Reference yield:

: 905589-27-7
(3S)-4-(tert-butyldiphenylsilyl)oxy-3-(triethylsilyl)oxy-butyraldehyde

: 132895-23-9
(S)-6-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxy-3-oxo-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / LDA / tetrahydrofuran / -78 °C

2: 81 percent / PDC, MS-4A / CH₂Cl₂ / Ambient temperature

3: 96 percent / aq. AcOH / tetrahydrofuran / Ambient temperature

With dipyridinium dichromate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.38.2890