4-CHLORO-6-NITROQUINOLINE

Base Information

• Chemical Name: 4-CHLORO-6-NITROQUINOLINE
• CAS No.: 13675-94-0
• Molecular Formula: C9H5ClN2O2
• Molecular Weight: 208.604
• Hs Code.: 2933499090
• Mol file: 13675-94-0.mol

Synonyms:4-Chloro-6-nitroquinoline;NSC 146766;

Chemical Property of 4-CHLORO-6-NITROQUINOLINE

Chemical Property:

• Vapor Pressure: 8.35E-05mmHg at 25°C
• Melting Point: 142.5 °C
• Refractive Index: 1.688
• Boiling Point: 351.397 °C at 760 mmHg
• PKA: 1.82±0.16(Predicted)
• Flash Point: 166.319 °C
• PSA: 58.71000
• Density: 1.484 g/cm³
• LogP: 3.31960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-6-nitroquinoline is used as a reactant in the preparation of arylaminoquinoline derivatives as potent inhibitors of epidermal growth factor receptor.

Technology Process of 4-CHLORO-6-NITROQUINOLINE

There total 12 articles about 4-CHLORO-6-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-hydroxy-6-nitro-quinoline (23432-42-0) → 4-chloro-6-nitroquinoline (13675-94-0)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; at 100 ℃; for 5h; Sealed tube; Inert atmosphere;

DOI:10.1055/a-0968-1150

Reference yield: 73.0%

6-nitroquinoline-4(1H)-one (21873-49-4) → 4-chloro-6-nitroquinoline (13675-94-0)

Guidance literature:

With trichlorophosphate; for 5h; Heating;

DOI:10.1016/j.bmc.2004.03.076

Reference yield:

6-nitroquinazolone (6943-17-5) → 4-chloro-6-nitroquinoline (13675-94-0)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 0.166667h; microwave irradiation;

upstream raw materials:

6-nitroquinoline-N-oxide

4-hydroxy-6-nitro-quinoline

6-nitroquinoline-4(1H)-one

4(1H)-quinolinone

Downstream raw materials:

6-nitro-4-phenoxy-quinoline

4-chloroquinolin-6-amine

6-nitro-[4]quinolylamine

4-((R)-3-Methyl-piperazin-1-yl)-6-nitro-quinoline

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