1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene

Base Information

• Chemical Name: 1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene
• CAS No.: 852672-52-7
• Molecular Formula: C₁₈H₂₀O₃S
• Molecular Weight: 316.421
• Mol file: 852672-52-7.mol

Synonyms:1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene

Chemical Property of 1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene

There total 2 articles about 1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-methyl p-tolyl sulfoxide (1519-39-7) + 2-(methoxymethoxy)-4-methylbenzaldehyde (98324-20-0) → 1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene (852672-52-7)

Guidance literature:

(R)-methyl p-tolyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

2-(methoxymethoxy)-4-methylbenzaldehyde; In tetrahydrofuran; at -78 - 20 ℃;

With sodium hydride; methyl iodide; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2005.03.005

Reference yield:

4-methylsalicylaldehyde (698-27-1) → 1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene (852672-52-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.25 h

2.1: LDA / tetrahydrofuran / 0.25 h / -78 °C

2.2: tetrahydrofuran / -78 - 20 °C

2.3: 4.93 g / MeI; NaH / tetrahydrofuran / 2 h / 20 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/j.tetasy.2005.03.005

Reference yield: 95.0%

1-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-2-(methoxymethoxy)-4-methylbenzene (852672-52-7) → 2-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-5-methylphenol (852672-53-8)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.tetasy.2005.03.005

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

2-(methoxymethoxy)-4-methylbenzaldehyde

4-methylsalicylaldehyde

Downstream raw materials:

2-((R)-(E)-2-(p-tolylsulfinyl)vinyl)-5-methylphenol

2-((R)-4-hydroxybutan-2-yl)-5-methylphenol

2-((R)-4-iodobutan-2-yl)-5-methylphenol

2-((S)-4-iodobutan-2-yl)-5-methylphenol