(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride
CAS No.:1428848-08-1
Molecular Formula:C₃₅H₃₉Cl₂F₂N₃O₁₀S₂*ClH
Molecular Weight:871.205
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

There total 9 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.3%

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1428848-12-7
4-(2-(N-(5-((carboxymethylthio)carbonyl)-2-methoxyphenyl)methylsulfonamido)ethyl)morpholin-4-ium 2,2,2-trifluoroacetate

: 1428848-08-1
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 2840-26-8
3-amino-4-methoxybenzoic acid

: 1428848-08-1
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: pyridine / 1 h / 0 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4.1: 5%-palladium/activated carbon; hydrogen / methanol / 0.5 h / 1810.07 Torr

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1.17 h / 20 °C

5.2: 2 h

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; 5%-palladium/activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 167993-22-8
benzyl 3-amino-4-methoxybenzoate

: 1428848-08-1
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(4-methoxy-3-(N-(2-morpholinoethyl)methylsulfonamido)benzoylthio)acetoxy)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 1 h / 0 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3.1: 5%-palladium/activated carbon; hydrogen / methanol / 0.5 h / 1810.07 Torr

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 1.17 h / 20 °C

4.2: 2 h

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; 5%-palladium/activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;