<2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

Base Information

Chemical Name:<2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril
CAS No.:133812-91-6
Molecular Formula:C₂₀H₂₅NO₂
Molecular Weight:311.424
Hs Code.:

Synonyms:<2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

Chemical Property:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of <2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

There total 1 articles about <2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.7%

: 532-28-5,613-88-7
(RS)-mandelonitrile

: 108031-76-1
<2R-(2α,3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-ol

: 133812-91-6
<2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

: 135028-68-1
<2S-(2a(R*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1007/BF00810829

Reference yield: 100.0%

: 133812-91-6
<2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

: <2S-(2α(R*),3aα,4β,7β,7aα)>-α-<(Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzeneacetaldehyde

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; 1.) -60 deg C, 10 min, 2.) r.t., 3 h;

Reference yield:

: 133812-91-6
<2S-(2a(S*),3aα,4β,7β,7aα)>-α-<(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy>benzolacetonitril

: 3198-15-0
(1R,2S)-(-)-norephedrine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 2) LiAlH₄ / 1) ether, 2 h, room temp., 2) 15 h, -50 deg C up to 10 deg C

2: 96 percent / 2 N HCl / methanol / 2 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; In methanol;
DOI:10.1007/BF00810829