tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

Base Information

Chemical Name:tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate
CAS No.:174809-63-3
Molecular Formula:C₂₃H₃₉N₂O₆P
Molecular Weight:470.546
Hs Code.:

Synonyms:tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

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Chemical Property of tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

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Technology Process of tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

There total 3 articles about tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 66447-17-4
tert-butyl phosphinate

: 174809-61-1
(S)-N,N'-di(tert-butoxycarbonyl)-1,2-diamino-(4-iodophenyl)propane

: 174809-63-3
tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In toluene; acetonitrile; at 90 ℃; for 1.66667h;
DOI:10.1021/jo9804590

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174809-63-3
tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1: 21.7 g / NaHCO₃ / methanol / 8 h / Ambient temperature

2: 75 percent / (Ph₃P)2PdCl₂, Et₃N / toluene; acetonitrile / 1.67 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; triethylamine; In methanol; toluene; acetonitrile;
DOI:10.1021/jo9804590

Reference yield:

: (S)-3-(4-Iodo-phenyl)-propane-1,2-diamine; hydrochloride

: 174809-63-3
tert-butyl (4-((2S)-di(tert-butoxycarbonylamino)propyl)phenyl)phosphinate

Guidance literature:: Multi-step reaction with 2 steps

1: 21.7 g / NaHCO₃ / methanol / 8 h / Ambient temperature

2: 75 percent / (Ph₃P)2PdCl₂, Et₃N / toluene; acetonitrile / 1.67 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; triethylamine; In methanol; toluene; acetonitrile;
DOI:10.1021/jo9804590