4-nitrophenethyl tert-butylphosphonate

Base Information

• Chemical Name: 4-nitrophenethyl tert-butylphosphonate
• CAS No.: 387338-37-6
• Molecular Formula: C₁₂H₁₈NO₅P
• Molecular Weight: 287.252
• Mol file: 387338-37-6.mol

Synonyms:4-nitrophenethyl tert-butylphosphonate

Chemical Property of 4-nitrophenethyl tert-butylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-nitrophenethyl tert-butylphosphonate

There total 1 articles about 4-nitrophenethyl tert-butylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

tert-butyl phosphinyl dichloride (4707-95-3) + 2-(4-nitrophenyl)ethanol (100-27-6) → 4-nitrophenethyl tert-butylphosphonate (387338-37-6)

Guidance literature:

2-(4-nitrophenyl)ethanol; With sodium hydride; In 1,4-dioxane; at 25 ℃; for 0.0833333h;

tert-butyl phosphinyl dichloride; In 1,4-dioxane; at 50 ℃; for 1h;

With water; at 50 ℃; for 0.75h; Further stages.;

DOI:10.1002/1521-3765(20011105)7:21<4604::AID-CHEM4604>3.0.CO;2-Z

Reference yield:

4-nitrophenethyl tert-butylphosphonate (387338-37-6) → tert-butyl-phosphonic acid mono-[2-(4-amino-phenyl)-ethyl] ester

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 760.051 Torr;

DOI:10.1002/1521-3765(20011105)7:21<4604::AID-CHEM4604>3.0.CO;2-Z

Reference yield:

4-nitrophenethyl tert-butylphosphonate (387338-37-6) → 4-[4-[2-(tert-butylphosphonyl)oxyethyl]phenylcarbamoyl]butyric acid

Guidance literature:

Multi-step reaction with 2 steps

1: 86 mg / H₂ / Pd/C / methanol / 3 h / 760.05 Torr

2: 92 mg / CH₂Cl₂ / 3 h / 25 °C

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/1521-3765(20011105)7:21<4604::AID-CHEM4604>3.0.CO;2-Z

upstream raw materials:

tert-butyl phosphinyl dichloride

2-(4-nitrophenyl)ethanol