Ala-Val-Leu-OBn

Base Information

• Chemical Name: Ala-Val-Leu-OBn
• CAS No.: 1565841-47-5
• Molecular Formula: C₂₁H₃₃N₃O₄
• Molecular Weight: 391.511
• Mol file: 1565841-47-5.mol

Synonyms:Ala-Val-Leu-OBn

Chemical Property of Ala-Val-Leu-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ala-Val-Leu-OBn

There total 8 articles about Ala-Val-Leu-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Ala-Val-Leu-OBzl → Ala-Val-Leu-OBn (1565841-47-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → Ala-Val-Leu-OBn (1565841-47-5)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydroxide / 1,4-dioxane; water / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Cooling with ice

3: trifluoroacetic acid / dichloromethane / 20 °C

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

5: trifluoroacetic acid / dichloromethane / 20 °C

6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

7: trifluoroacetic acid / dichloromethane / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

L-Leucine benzyl ester (1738-69-8) → Ala-Val-Leu-OBn (1565841-47-5)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling with ice

2: trifluoroacetic acid / dichloromethane / 20 °C

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

L-leucine

N-tert-butoxycarbonyl-L-leucine

2-tert-butoxycarbonylamino-4-methyl-penatnoic acid benzyl ester

L-Leucine benzyl ester

Downstream raw materials:

H₂N-Ala-Val-Leu-OH