9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene

Base Information

• Chemical Name: 9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene
• CAS No.: 98421-61-5
• Molecular Formula: C₂₈H₂₂Cl₂O
• Molecular Weight: 445.388
• Mol file: 98421-61-5.mol

Synonyms:9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene

Chemical Property of 9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene

There total 1 articles about 9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9,9-bis(3-chloro-2-methylphenyl)-10-oxo-9,10-dihydrophenanthrene (98421-60-4) → 9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene (98421-61-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.5h; Yield given; Heating;

DOI:10.1021/ja00309a042

Reference yield:

9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene (98421-61-5) → 9,10-bis(3-chloro-2-methylphenyl)phenanthrene (98421-62-6)

Guidance literature:

With iodine; In acetic acid; for 1.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/ja00309a042

Reference yield:

9,9-bis(3-chloro-2-methylphenyl)-10-hydroxy-9,10-dihydrophenanthrene (98421-61-5) → syn-9,10-bis<3-(bromomethyl)-2-methylphenyl>phenanthrene (98421-64-8,122741-68-8)

Guidance literature:

Multi-step reaction with 6 steps

1: iodine / aq. acetic acid / 1.5 h / Heating

2: 92 percent / various solvent(s) / 30 h / Heating

3: LiAlH₄ / tetrahydrofuran / 1 h / Heating

4: sodium nitrite / H₂O / 0.33 h / Ambient temperature

5: NaOH / methanol; H₂O / 2 h / Heating

6: 84 percent / PBr₃, pyridine / benzene / 15 h

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; iodine; phosphorus tribromide; sodium nitrite; In tetrahydrofuran; methanol; water; acetic acid; benzene;

DOI:10.1021/ja00309a042

upstream raw materials:

9,9-bis(3-chloro-2-methylphenyl)-10-oxo-9,10-dihydrophenanthrene

Downstream raw materials:

9,10-bis(3-chloro-2-methylphenyl)phenanthrene

syn-9,10-bis<3-(bromomethyl)-2-methylphenyl>phenanthrene

9,10-bis(3-cyano-2-methylphenyl)phenanthrene

syn-9,10-bis<3-(hydroxymethyl)-2-methylphenyl>phenanthrene